Yu-Gi-Oh! Monster Capsule: Breed and Battle primarily features characters from the Yu-Gi-Oh! manga. The player raises and trains Capsule Monsters to defeat opponents in a tournament. Opponents include Yugi Mutou, Katsuya Jonouchi, Anzu Mazaki, Mokuba Kaiba, Ryo Bakura, Sugoroku Mutou, Seto Kaiba and Dark Yugi.

Yu-Gi-Oh! Monster Capsule: Breed and Battle primarily features characters from the Yu-Gi-Oh! manga. The player raises and trains Capsule Monsters to defeat opponents in a tournament. Opponents include Yugi Mutou, Katsuya Jonouchi, Anzu Mazaki, Mokuba Kaiba, Ryo Bakura, Sugoroku Mutou, Seto Kaiba and Dark Yugi.