The game includes a single-player story mode (known as "Advanced UNO") set in a private high school. Players control Shunichi Uno, a hot-blooded Uno player who seeks to defeat the other members of the school's Uno Club to participate in the National High School Uno Championship.

The game includes a single-player story mode (known as "Advanced UNO") set in a private high school. Players control Shunichi Uno, a hot-blooded Uno player who seeks to defeat the other members of the school's Uno Club to participate in the National High School Uno Championship.