April has been kidnapped once again by the Shredder, Krang and cohorts, and Leonardo, Michelangelo, Raphael, and Donatello set out to rescue her from their enemies' clutches. The chase leads them through the sewers and the streets of New York City, the river, and then the Technodrome.

April has been kidnapped once again by the Shredder, Krang and cohorts, and Leonardo, Michelangelo, Raphael, and Donatello set out to rescue her from their enemies' clutches. The chase leads them through the sewers and the streets of New York City, the river, and then the Technodrome.