Shantae and the Seven Sirens finds Shantae and her friends on vacation at Paradise Island, where they encounter other Half-Genies, and Shantae is invited to the Half-Genie Festival. However, she soon discovers that things are not as they seem as the other Half-Genies are kidnapped. It is left to Shantae to explore the ancient Sunken City and overcome its treacherous labyrinths to rescue the other Half-Genies and find out they were abducted. Along the way, she discovers new dance abilities and instant-transformation Fusion Magic, and battles the mysterious rulers of the Sunken City, the Seven Sirens. However, she also ends up encountering her longtime nemesis Risky Boots, who seeks a mysterious treasure said to reside beneath the island.

Shantae and the Seven Sirens finds Shantae and her friends on vacation at Paradise Island, where they encounter other Half-Genies, and Shantae is invited to the Half-Genie Festival. However, she soon discovers that things are not as they seem as the other Half-Genies are kidnapped. It is left to Shantae to explore the ancient Sunken City and overcome its treacherous labyrinths to rescue the other Half-Genies and find out they were abducted. Along the way, she discovers new dance abilities and instant-transformation Fusion Magic, and battles the mysterious rulers of the Sunken City, the Seven Sirens. However, she also ends up encountering her longtime nemesis Risky Boots, who seeks a mysterious treasure said to reside beneath the island.