Unlike the first three games in the franchise, Saints Row 4 does not center around the main character defeating three rival gangs in order to take over a city. The Saints have now become a household name, and their leader has become the president of the Unites States. The antagonists in Saints Row 4 are an invading alien race known as the Zin. Most of the game takes place within a computer simulation of the city of Steelport controlled by the Zin, where the protagonist is attempting to free himself and his companions.

Unlike the first three games in the franchise, Saints Row 4 does not center around the main character defeating three rival gangs in order to take over a city. The Saints have now become a household name, and their leader has become the president of the Unites States. The antagonists in Saints Row 4 are an invading alien race known as the Zin. Most of the game takes place within a computer simulation of the city of Steelport controlled by the Zin, where the protagonist is attempting to free himself and his companions.