The story follows the downfall of the bioengineering pharmaceutical company Umbrella Corporation by revisiting scenarios of earlier games in the series, such as Resident Evil Zero, Resident Evil, Resident Evil 2, and Resident Evil 3: Nemesis, divided over four main chapters with ten scenarios in total.

The story follows the downfall of the bioengineering pharmaceutical company Umbrella Corporation by revisiting scenarios of earlier games in the series, such as Resident Evil Zero, Resident Evil, Resident Evil 2, and Resident Evil 3: Nemesis, divided over four main chapters with ten scenarios in total.