The game's main protagonist is Leon S. Kennedy, one of the few survivors of the Raccoon City incident, who was recruited and trained by the US Government to become a special agent after they learned of his actions in Raccoon City. Now an agent for a special security agency, Leon is sent to Spain on a mission to rescue Ashley Graham, the President's daughter, who has been kidnapped by a mysterious cult organization.

The game's main protagonist is Leon S. Kennedy, one of the few survivors of the Raccoon City incident, who was recruited and trained by the US Government to become a special agent after they learned of his actions in Raccoon City. Now an agent for a special security agency, Leon is sent to Spain on a mission to rescue Ashley Graham, the President's daughter, who has been kidnapped by a mysterious cult organization.