The game is set on September 29, 1998. Zombies have infested Raccoon City. A biological weapon known as the T-Virus was released into the sewer system. Rats then spread the virus to the city's population. Two people make their way to Raccoon City: Leon S. Kennedy, a rookie police officer on his first day on the job, and Claire Redfield, a college student looking for her brother. Leon and Claire quickly find themselves fighting for their lives against hordes of creatures in their search for survival.

The game is set on September 29, 1998. Zombies have infested Raccoon City. A biological weapon known as the T-Virus was released into the sewer system. Rats then spread the virus to the city's population. Two people make their way to Raccoon City: Leon S. Kennedy, a rookie police officer on his first day on the job, and Claire Redfield, a college student looking for her brother. Leon and Claire quickly find themselves fighting for their lives against hordes of creatures in their search for survival.