One of 12 nuclear anomalies/ mutant creatures embarks on a quest across various post- apocalyptic dimensions to claim the Nuclear Throne - a super weapon, details of whose purpose or creation unknown. Meanwhile, the Inter-Dimensional Police Department try their best not to let the mutant heroes discover the secrets of portal-based inter-dimensional travel and the Throne.

One of 12 nuclear anomalies/ mutant creatures embarks on a quest across various post- apocalyptic dimensions to claim the Nuclear Throne - a super weapon, details of whose purpose or creation unknown. Meanwhile, the Inter-Dimensional Police Department try their best not to let the mutant heroes discover the secrets of portal-based inter-dimensional travel and the Throne.