Following the events of HITMAN, Agent 47 embarks on a mission to hunt the mysterious "Shadow Client" for Providence, a secretive organization that controls most of the world's affairs. 47's employers, the International Contract Agency (ICA), have formed an uneasy alliance with Providence to stop the Shadow Client, whose actions are causing global panic, and 47 has agreed to help in return for Providence revealing his past.

Following the events of HITMAN, Agent 47 embarks on a mission to hunt the mysterious "Shadow Client" for Providence, a secretive organization that controls most of the world's affairs. 47's employers, the International Contract Agency (ICA), have formed an uneasy alliance with Providence to stop the Shadow Client, whose actions are causing global panic, and 47 has agreed to help in return for Providence revealing his past.