The story follows Nero, a man possessing demonic powers who is on a mission to stop the series' main character, Dante, after he assassinates the leader of the Order of the Sword. The player assumes the role of both Nero and Dante as they fight enemies using their demonic powers and a variety of weapons.

The story follows Nero, a man possessing demonic powers who is on a mission to stop the series' main character, Dante, after he assassinates the leader of the Order of the Sword. The player assumes the role of both Nero and Dante as they fight enemies using their demonic powers and a variety of weapons.