Engineer Isaac Clarke is dispatched on a repair mission to the USG Ishimura, a mining vessel suffering a communications blackout. Isaac, accompanied by Chief Security Officer Zach Hammond, and Computer Specialist Kendra Daniels, become stranded on a seemingly derelict ship, where a newborn horror awaits them.

Engineer Isaac Clarke is dispatched on a repair mission to the USG Ishimura, a mining vessel suffering a communications blackout. Isaac, accompanied by Chief Security Officer Zach Hammond, and Computer Specialist Kendra Daniels, become stranded on a seemingly derelict ship, where a newborn horror awaits them.